Paternally multi-generational high-fat diet causes obesity and metabolic disorder through intergenerational DNA methylation
This research shows that paternal sustained multi-generational HFD could induce intergenerational progressive accumulation of obesity and metabolic disorder through DNA methylation regulation, and identifies the target genes related to the intergenerational reprogramming, which provides new insights for the establishment of healthy diets and lifestyles.
Authors
- Feijun Luo (ORCID: https://orcid.org/0000-0001-7489-544X)
- Zuomin Hu (ORCID: https://orcid.org/0000-0001-8110-292X)
- Tianyi Guo (ORCID: https://orcid.org/0000-0002-3369-6708)
- Liyuan Bao
- Mingzhi Wang
- Yan Li (ORCID: https://orcid.org/0000-0003-0815-3565)
- Yunyun Cao (ORCID: https://orcid.org/0000-0002-0562-6577)
- Zhongxing Chu (ORCID: https://orcid.org/0009-0009-7078-2267)
Institutions
- Central South University of Forestry and Technology (CN)
- Central South University (CN)
- Changzhi Medical College (CN)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2025-10-27
- DOI
- https://doi.org/10.3389/fnut.2025.1680793
- Citations
- 1
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.81