Investigating the causal role of cellular senescence-related genes in preeclampsia: a multi-omics Mendelian randomization study with differential expression analysis
Placental RT-PCR showed upregulated <i>ATG16L1</i> and downregulated <i>PMVK</i>, <i>MAP3K14</i>, <i>NSUN2</i>, and <i>CDC25A</i> in preeclampsia. Key genes (<i>ATG16L1</i>, <i>PMVK</i>, <i>MAP3K14</i>, <i>NSUN2</i>, <i>CDC25A</i>) link cellular senescence to preeclampsia, offering insights for mechanistic studies and therapeutic targeting.
Authors
- Weirong Gu (ORCID: https://orcid.org/0000-0002-2157-0454)
- Rong Hu
- Zhenzhen Liu (ORCID: https://orcid.org/0000-0002-8313-3444)
- Xiaoyue Zhang (ORCID: https://orcid.org/0000-0002-9381-8930)
- Jue Wang (ORCID: https://orcid.org/0000-0001-8013-0486)
- Yi Yu
- Hao Zhu (ORCID: https://orcid.org/0009-0004-0320-9990)
- Chengjie Wang (ORCID: https://orcid.org/0000-0001-8147-3704)
Institutions
- Obstetrics and Gynecology Hospital of Fudan University (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-10-27
- DOI
- https://doi.org/10.3389/fendo.2025.1661666
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shanghai Municipal Health Commission