Bone marrow mesenchymal stem cells alleviate smoke inhalation injury by regulating alveolar macrophage polarization via the CD200-CD200R pathway
Our findings identify the immune checkpoint molecule CD200 as an anti-inflammatory target in the regulation of alveolar macrophages by BMSCs and provide new insights for more effective and precise MSC-based cell therapy.
Authors
- Ziling Ding
- Yunlong Zhao (ORCID: https://orcid.org/0000-0002-7166-2592)
- Qi Lv (ORCID: https://orcid.org/0000-0001-9076-7042)
- Haojun Fan (ORCID: https://orcid.org/0000-0003-1111-0232)
- Jie Shi (ORCID: https://orcid.org/0000-0002-4302-6556)
- Xiaoqin Guo (ORCID: https://orcid.org/0000-0003-1647-4385)
- Yong Zhuang (ORCID: https://orcid.org/0000-0002-2709-8330)
Institutions
- Tianjin University of Technology (CN)
- Wenzhou University (CN)
- Tianjin University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-27
- DOI
- https://doi.org/10.3389/fimmu.2025.1645460
- Citations
- 1
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.80