Genetically instrumented circulating metabolites and hepatobiliary cancer risk: A multi-tiered Mendelian randomization and functional interrogation
These findings advance understanding of metabolic dysregulation in hepatobiliary malignancies and nominate candidate diagnostic biomarkers and therapeutic targets, providing translationally relevant hypotheses for precision medicine.
Authors
- Xing Yang (ORCID: https://orcid.org/0000-0001-5186-4990)
- Shu Wang (ORCID: https://orcid.org/0000-0002-3598-6055)
- Ying Liu (ORCID: https://orcid.org/0000-0003-2408-3712)
- Yan Li (ORCID: https://orcid.org/0000-0002-5938-8519)
- Lin Tuo
- Xiang An (ORCID: https://orcid.org/0009-0004-3167-4072)
Institutions
- University of Electronic Science and Technology of China (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-10-27
- DOI
- https://doi.org/10.3389/fonc.2025.1680865
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China