Clinical characteristics and survival outcomes of extrapulmonary neuroendocrine carcinomas: a retrospective study
EPNEC prognosis is influenced by tumor site, stage, lymph node involvement, and biomarker levels. Surgery is optimal for early-stage disease (I/II), while chemotherapy and radiotherapy provide survival benefits in advanced-stage (III/IV) patients. Combined CEA and NSE elevation indicates a particularly poor prognosis. These findings highlight the importance of individualized, stage- and biomarker-driven therapeutic strategies for EPNECs.
Authors
- Benjie Xu
- Haibo Lu (ORCID: https://orcid.org/0000-0002-7161-1146)
- Yuanyuan Li (ORCID: https://orcid.org/0000-0002-6959-4682)
- Junhao Xu (ORCID: https://orcid.org/0000-0002-7910-4165)
- Jie Lian (ORCID: https://orcid.org/0000-0002-7237-7347)
Institutions
- Harbin Medical University (CN)
- Third Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-10-27
- DOI
- https://doi.org/10.3389/fendo.2025.1635630
- Citations
- 1
- Primary Topic
- Neuroendocrine Tumor Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- Harbin Medical University
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation