Primary high-grade urothelial carcinoma of the prostate combined with acinar adenocarcinoma: first rare case report and treatment experience summary
This case underscores the diagnostic challenges of prostatic urothelial carcinoma and highlights the importance of immunohistochemistry in cases with normal PSA but rapid progression. The protocol of surgery combined with targeted and immunotherapy offers a new treatment strategy for this rare malignancy. This study provides valuable insights for clinical diagnosis and management.
Authors
- Jinze Zhang
- Fang Zhou (ORCID: https://orcid.org/0000-0002-8271-4116)
- Yu Nie (ORCID: https://orcid.org/0000-0002-8744-0046)
- Céline Gu (ORCID: https://orcid.org/0009-0008-1700-301X)
- Guopeng Wang
- Dong Wang (ORCID: https://orcid.org/0000-0002-7539-9963)
- Shangqing Ren
- Yisha Liu
- Ting Hu
Institutions
- University of Electronic Science and Technology of China (CN)
- Southwest Medical University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-10-27
- DOI
- https://doi.org/10.3389/fonc.2025.1649636
- Primary Topic
- Bladder and Urothelial Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00