Clinical and tumor features of patients with immune checkpoint inhibitor-related neurological disorders and anti-Yo antibodies
Post-ICI anti-Yo neurological syndromes may occur with atypical cancer associations, but mostly manifest with a RCPS indistinguishable from spontaneous anti-Yo paraneoplastic neurological syndromes, suggesting a similar immune-mediated attack on the cerebellum. The CDR2L antigen overexpression and the pre-ICI anti-Yo antibody positivity in the patient with ovarian cancer suggest that the ICI boosted a pre-formed, tumor-driven anti-Yo autoimmunity. Further studies are needed to clarify whether this mechanism applies to all patients and if other types of tumor alterations and/or immune dysfunctions could be involved.
Authors
- Antonio Farina (ORCID: https://orcid.org/0000-0002-5551-0185)
- Virginie Desestret (ORCID: https://orcid.org/0000-0001-9643-1558)
- David Meyronet (ORCID: https://orcid.org/0000-0001-9943-4578)
- Marie Bénaiteau
- Elise Peter (ORCID: https://orcid.org/0000-0002-7898-8069)
- Valentin Wucher (ORCID: https://orcid.org/0000-0002-1331-4549)
- Géraldine Picard (ORCID: https://orcid.org/0000-0003-1282-267X)
- Le Duy (ORCID: https://orcid.org/0000-0001-7664-533X)
- Celeste Nicola (ORCID: https://orcid.org/0009-0000-3202-5489)
- Marine Villard (ORCID: https://orcid.org/0000-0002-1061-2321)
- Macarena Villagrán‐García (ORCID: https://orcid.org/0000-0001-9236-2428)
- Véronique Rogemond (ORCID: https://orcid.org/0000-0003-2098-920X)
- Jérôme Honnorat (ORCID: https://orcid.org/0000-0002-4721-5952)
- Isabelle Treilleux (ORCID: https://orcid.org/0000-0003-3919-5506)
- Bastien Joubert (ORCID: https://orcid.org/0000-0003-4631-3056)
- Daniel Pissaloux (ORCID: https://orcid.org/0000-0003-1118-950X)
- Nolwenn Billet
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Hospices Civils de Lyon (FR)
- Centre Léon Bérard (FR)
- Hôpital Pierre Wertheimer (FR)
- Centre de Recherche en Cancérologie de Lyon (FR)
- Institut NeuroMyoGène (FR)
Publication Details
- Journal
- Therapeutic Advances in Neurological Disorders
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1177/17562864251377559
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00