Transcriptome Sequencing Identifies PCK1 and IRS4 as Key Regulators of Gestational Diabetes Mellitus in Placenta: A Pilot Study
These findings highlight the roles of placental PCK1 and IRS4 in GDM. Further mechanistic studies, including protein-level validation and animal models, are warranted to explore these pathways as potential diagnostic or therapeutic targets for GDM.
Authors
- Wenwen Wang (ORCID: https://orcid.org/0000-0002-3937-7214)
- Qianrui Zhang
- Jing Lü (ORCID: https://orcid.org/0000-0002-9568-0031)
- Li Zhou (ORCID: https://orcid.org/0000-0002-3511-3449)
Institutions
- Beijing Tongren Hospital (CN)
Publication Details
- Journal
- Diabetes Metabolic Syndrome and Obesity
- Published
- 2025-10-01
- DOI
- https://doi.org/10.2147/dmso.s542175
- Citations
- 1
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 2.06