Nickel/Photoredox‐Catalyzed Reductive Aldol Reaction
A dual nickel/photoredox‐catalyzed reductive aldol reaction using readily available alkyl bromide and α‐silylamine as bench‐stable hydride source and organic reductant is reported. A variety of β‐hydroxyl carbonyl compounds can be efficiently synthesized under mild conditions. The reaction exhibits broad substrate scope, accommodating various (hetero)aromatic and aliphatic aldehydes, as well as acyclic and cyclic α,β‐unsaturated carbonyls.
Authors
- Weiming Yuan (ORCID: https://orcid.org/0000-0002-0766-960X)
- Wenlong Wang (ORCID: https://orcid.org/0000-0002-8978-9698)
- Long Wang (ORCID: https://orcid.org/0000-0001-6695-6054)
- Xianzhou Zheng
Institutions
- Ministry of Education (RO)
- Wuhan National Laboratory for Optoelectronics (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Advanced Synthesis & Catalysis
- Published
- 2025-10-26
- DOI
- https://doi.org/10.1002/adsc.70192
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00