Mechanochemical Nickel‐Catalyzed Suzuki–Miyaura Cross‐Coupling of Phenol‐Derived Cyanate Esters
A mechanochemical strategy has been developed for the nickel‐catalyzed Suzuki–Miyaura cross‐coupling of cyano esters derived from phenols, as electrophilic substrates using arylboronic acids via C sp 2 O bond cleavage. This approach capitalizes on the abundance of phenols, using cyano‐functionalized derivatives to enable high reactivity and functional group compatibility without halogenated reagents. The reaction is carried out under solvent‐free, temperature‐trace conditions, significantly reducing environmental impact. The methodology offers a sustainable and scalable alternative for biaryl synthesis, with implications for pharmaceutical and material sciences.
Authors
- Vitaliy Yepishev
- А. Г. Каплаушенко (ORCID: https://orcid.org/0000-0003-3704-5539)
- Viktor O. Iaroshenko (ORCID: https://orcid.org/0000-0002-5647-5326)
- Yu. V. Karpenko (ORCID: https://orcid.org/0000-0002-4390-9949)
- Yevhen Karpun (ORCID: https://orcid.org/0000-0003-1816-812X)
- Oleksandr Shalimov (ORCID: https://orcid.org/0000-0002-1538-3206)
- R. О. Shcherbyna (ORCID: https://orcid.org/0000-0002-9742-0284)
- Satenik Mkrtchyan (ORCID: https://orcid.org/0000-0001-7081-9802)
- Володимир Володимирович Парченко (ORCID: https://orcid.org/0000-0002-2283-1695)
- Gabriela Addová (ORCID: https://orcid.org/0000-0003-3534-309X)
- Juraj Filo (ORCID: https://orcid.org/0000-0002-3995-2565)
- Vishal B. Purohit (ORCID: https://orcid.org/0000-0002-9392-8136)
- Jiří Zapletal
Institutions
- TU Wien (AT)
- National Academy of Sciences of Ukraine (UA)
- National University of Life and Environmental Sciences of Ukraine (UA)
- Zaporizhzhia State Medical and Pharmaceutical University (UA)
- Charotar University of Science and Technology (IN)
- Interregional Academy of Personnel Management (UA)
- Institute of Organic Chemistry (UA)
- Georgian American University (GE)
- Matej Bel University (SK)
- Chitkara University (IN)
- Comenius University Bratislava (SK)
Publication Details
- Journal
- European Journal of Organic Chemistry
- Published
- 2025-10-26
- DOI
- https://doi.org/10.1002/ejoc.202500615
- Citations
- 1
- Primary Topic
- Catalytic Cross-Coupling Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.94