From childhood shadows to adult aches: a prospective cohort study on adverse childhood experiences, depressive symptoms, and incident arthritis in middle-aged and older Chinese adults
In this national cohort, higher ACEs burden and greater depressive symptom severity were significantly associated with incident arthritis, and depressive symptoms partially mediated by the ACEs-arthritis association. Targeting childhood adversity and later-life mental health may help reduce arthritis risk in aging populations.
Authors
- Gang Li (ORCID: https://orcid.org/0000-0002-8573-1608)
- Yuqi Guo (ORCID: https://orcid.org/0000-0002-7060-8404)
- Jiacheng Li (ORCID: https://orcid.org/0000-0003-4884-9786)
- Bo‐Wen Lu
- Mingtao Wen
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- Affiliated Hospital of Shandong University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-10-27
- DOI
- https://doi.org/10.1186/s40001-025-03226-7
- Primary Topic
- Child Abuse and Trauma
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Shandong Province
- Key Technology Research and Development Program of Shandong