CMTM6 drives glioblastoma progression by promoting M2 polarization and suppressing antigen presentation in microglia/macrophages
This study identifies CMTM6 as a critical regulator of the immunosuppressive phenotype of microglia/macrophages in GBM. Targeting CMTM6 in microglia/macrophages may represent a novel strategy to reprogram the tumor immune microenvironment and improve the efficacy of immunotherapy in GBM.
Authors
- Xiang Li (ORCID: https://orcid.org/0000-0002-1167-7485)
- Yuan Lyu (ORCID: https://orcid.org/0000-0003-4351-5672)
- Yi Chen (ORCID: https://orcid.org/0009-0009-0714-9274)
- Shan Qiao (ORCID: https://orcid.org/0000-0001-9685-0277)
- Wenbo Han (ORCID: https://orcid.org/0009-0005-1525-0509)
- Yi-Jung Yang (ORCID: https://orcid.org/0000-0001-9108-573X)
- Weiwei Cai (ORCID: https://orcid.org/0000-0002-7296-2730)
- Xiaohui Li (ORCID: https://orcid.org/0000-0002-0624-8811)
- Cheng Zhang (ORCID: https://orcid.org/0000-0001-5317-8775)
- Xinjun Wang (ORCID: https://orcid.org/0000-0001-5333-6980)
- Junqi Li (ORCID: https://orcid.org/0000-0003-3457-4099)
- Han Yang
- Gaojie Bai
- Xueli Tian (ORCID: https://orcid.org/0000-0002-7297-1311)
- C.Y. Sun
- Shuangkang Ge
- Xinyi Han (ORCID: https://orcid.org/0009-0002-4280-1917)
Institutions
- Zhengzhou University (CN)
- Fifth Affiliated Hospital of Zhengzhou University (CN)
- Luoyang Central Hospital Affiliated to Zhengzhou University (CN)
- Third Affiliated Hospital of Zhengzhou University (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-10-27
- DOI
- https://doi.org/10.1186/s40001-025-03243-6
- Citations
- 2
- Primary Topic
- Chemokine receptors and signaling
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- National Natural Science Foundation of China
- Henan Provincial Science and Technology Research Project