Distinct diurnal temperature rhythm patterns in critical illness myopathy: secondary analysis of two prospective trials

Heterogeneous phase shifts of diurnal temperature rhythms in CIM and no-CIM groups compared to healthy bed rest volunteers may indicate ICU-related circadian disruption. Suppression of temperature rhythm amplitude during ICU stay could represent an adaptive response to this disruption. Blunted amplitude suppression observed in CIM compared to no-CIM patients might reflect reduced adaptation, potentially contributing to muscle catabolism. This hypothesis-generating analysis underlines the need for mechanistic studies exploring circadian regulation in skeletal muscle during critical illness.

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Publication Details

Journal
Annals of Intensive Care
Published
2025-01-01
DOI
https://doi.org/10.1186/s13613-025-01582-5
Primary Topic
Intensive Care Unit Cognitive Disorders
Type
article
Field-Weighted Citation Impact
0.00
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article

Distinct diurnal temperature rhythm patterns in critical illness myopathy: secondary analysis of two prospective trials

Achim Kramer, Lilian Jo Engelhardt, Claudia Spies, Kerstin Rubarth et al.
Annals of Intensive Care
Intensive Care Unit Cognitive Disorders
article

Distinct diurnal temperature rhythm patterns in critical illness myopathy: secondary analysis of two prospective trials

Achim Kramer, Lilian Jo Engelhardt, Claudia Spies, Kerstin Rubarth, Laura Hancke, Darius Mewes, Sebastian Daniel Boie, Felix Balzer, Bharath Ananthasubramaniam, Jens Fielitz, Tobias Wollersheim, Friedrich Braune, S. Weber-Carstens, L. Spies
article en

Abstract

Heterogeneous phase shifts of diurnal temperature rhythms in CIM and no-CIM groups compared to healthy bed rest volunteers may indicate ICU-related circadian disruption. Suppression of temperature rhythm amplitude during ICU stay could represent an adaptive response to this disruption. Blunted amplitude suppression observed in CIM compared to no-CIM patients might reflect reduced adaptation, potentially contributing to muscle catabolism. This hypothesis-generating analysis underlines the need for mechanistic studies exploring circadian regulation in skeletal muscle during critical illness.

Annals of Intensive CareVol. 15(1)
Hasso Plattner Institute (DE), Universitätsmedizin Greifswald (DE), Humboldt-Universität zu Berlin (DE), German Centre for Cardiovascular Research (DE), Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE), Medizinische Hochschule Brandenburg Theodor Fontane (DE), Freie Universität Berlin (DE), Charité - Universitätsmedizin Berlin (DE)
Openalex Percentile: Top 64%
Intensive Care Unit Cognitive Disorders
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