Significance of positive semi-quantitative PCR tests on bronchoalveolar lavage for Pneumocystis jirovecii pneumonia in HIV-negative immunocompromised ICU patients with acute respiratory failure
Semi-quantitative PJ PCR was accurate in diagnosing PJP in non-HIV ICU patients with acute respiratory failure (ARF), and a Ct at low cycle values was more frequent in confirmed PJP than in colonization. The optimal Ct threshold was 30. The BDG assay was especially valuable when high levels were reached.
Authors
- Romain Sonneville (ORCID: https://orcid.org/0000-0003-0245-309X)
- Sandrine Houzé (ORCID: https://orcid.org/0000-0001-9016-3847)
- Christine Bonnal (ORCID: https://orcid.org/0000-0003-3030-5318)
- Paul-Henri Wicky (ORCID: https://orcid.org/0000-0002-1105-4667)
- Manuel Etienne (ORCID: https://orcid.org/0000-0002-7301-2614)
- Nicolas Argy (ORCID: https://orcid.org/0000-0002-0458-2664)
- Michaël Thy (ORCID: https://orcid.org/0000-0001-9366-505X)
- Julien Dessajan
- Louis-Maxime Vaconsin
- Lila Bouadma
- Jean-François Timsit
Institutions
- Inserm (FR)
- Délégation Paris 7 (FR)
- Université Paris Cité (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Paris Cardiovascular Research Center (FR)
Publication Details
- Journal
- Annals of Intensive Care
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1186/s13613-025-01568-3
- Citations
- 1
- Primary Topic
- Pneumocystis jirovecii pneumonia detection and treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.35