Relative Bioavailability of Inhaled Fluticasone Propionate and Salmeterol – is Population Pharmacokinetic Modelling a Relevant Alternative to a Non-Compartmental Approach?

Model- and NCA-based approaches to assess bioequivalence were consistent. However, a frequentist parametric approach that fully utilizes the population analysis potential and mechanistically predicts regional pulmonary deposition of FP and SALM would require a demographically more heterogenous data set and analysis including additional outcomes of parenteral and oral administration to discriminate presystemic from systemic disposition.