Polydatin enhances blood vessel relaxation and reduces NLRP3-mediated inflammation in hyperglycemia by lowering vascular cell adhesion molecule expression
Polydatin counteracts hyperglycemia-induced endothelial dysfunction by enhancing eNOS-dependent NO signaling to restore vasodilatory capacity, while inhibiting NLRP3 inflammasome activation and downstream VCAM-1 expression to attenuate vascular inflammation. These dual mechanisms position polydatin as a therapeutic agent for preserving vascular function in diabeticconditions.
Authors
- Syed Ali Raza Naqvi (ORCID: https://orcid.org/0000-0002-2172-9066)
- Wahid Shah (ORCID: https://orcid.org/0000-0002-3844-0592)
- Imran Ali (ORCID: https://orcid.org/0000-0002-7891-8511)
- Arshad Mehmood (ORCID: https://orcid.org/0000-0002-7547-4767)
- Muhammad Shoaib (ORCID: https://orcid.org/0000-0003-3357-4919)
Institutions
- Hebei Medical University (CN)
- Shanxi Medical University (CN)
- Southeast University (BD)
- First Hospital of Shanxi Medical University (CN)
- Shanxi Academy of Medical Sciences (CN)
- State Key Laboratory of Digital Medical Engineering (CN)
- Southeast University (CN)
Publication Details
- Journal
- Immunopharmacology and Immunotoxicology
- Published
- 2025-10-26
- DOI
- https://doi.org/10.1080/08923973.2025.2572548
- Primary Topic
- Adipokines, Inflammation, and Metabolic Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00