Examining the Concordance of Detection of Hereditary Cancer Gene Variants Between Blood, Tumour, and Normal Tissue in Patients with High-Grade Serous Ovarian Carcinoma
NGS testing of normal tissue at surgical resection reliably identifies germline pathogenic variants in patients with HGSOC. Incorporating this approach may help triage patients for clinical genetics assessment.
Authors
- C. Meg McLachlin (ORCID: https://orcid.org/0000-0002-3518-7376)
- L. M. Mui (ORCID: https://orcid.org/0009-0000-4389-1614)
- Jacob McGee (ORCID: https://orcid.org/0000-0003-3210-0682)
- Jennifer Kerkhof (ORCID: https://orcid.org/0000-0003-1245-6606)
- Bekim Sadiković (ORCID: https://orcid.org/0000-0001-6363-0016)
- Karen Panabaker
- Emily A. Goebel (ORCID: https://orcid.org/0000-0002-9338-8926)
Institutions
- Western University (CA)
- London Health Sciences Centre (CA)
Publication Details
- Journal
- Genes
- Published
- 2025-10-25
- DOI
- https://doi.org/10.3390/genes16111260
- Primary Topic
- BRCA gene mutations in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00