Low Oxygen Saturation During Risperidone Therapy: A Multispecialty Approach

Risperidone is an atypical antipsychotic medication commonly used in the treatment of schizophrenia and bipolar disorder in adults. Risperidone therapy is not typically associated with low oxygen saturation. However, recurrent severe acute respiratory distress and acute eosinophilic pneumonia have been documented during risperidone treatment, accompanied by low oxygen saturation and requiring respiratory support. There is a paucity of literature describing low oxygen saturation without acute respiratory compromise during risperidone therapy. Therefore, we present a rare case of low oxygen saturation in a patient with glucose-6-phosphate dehydrogenase (G6PD) deficiency and variant hemoglobin (elevated HbA₂) on risperidone therapy, who exhibited no respiratory compromise.

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Publication Details

Journal
Cureus
Published
2025-10-26
DOI
https://doi.org/10.7759/cureus.95464
Citations
1
Primary Topic
Treatment of Major Depression
Type
article
Field-Weighted Citation Impact
1.39
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article

Low Oxygen Saturation During Risperidone Therapy: A Multispecialty Approach

Olasumbo Elizabeth Fagbenle, Ogochukwu Agazie, Evaristus Chino Ezema, Chidalu Ibeneme et al.
1 citations
Cureus
Treatment of Major Depression
1.39
article

Low Oxygen Saturation During Risperidone Therapy: A Multispecialty Approach

Olasumbo Elizabeth Fagbenle, Ogochukwu Agazie, Evaristus Chino Ezema, Chidalu Ibeneme, Olaniyi D. Ogundeji, Chinenye Loveth Aleke, Omotola Emmanuel, Nnenna Bessie Emejuru, Gideon Onyebuchi Idoko, Samuel Alao, Cheikh S. Galledou, Amarachi N Abanobi, Oluseye O Asaolu, M Sanmi
article en
1 citations

Abstract

Risperidone is an atypical antipsychotic medication commonly used in the treatment of schizophrenia and bipolar disorder in adults. Risperidone therapy is not typically associated with low oxygen saturation. However, recurrent severe acute respiratory distress and acute eosinophilic pneumonia have been documented during risperidone treatment, accompanied by low oxygen saturation and requiring respiratory support. There is a paucity of literature describing low oxygen saturation without acute respiratory compromise during risperidone therapy. Therefore, we present a rare case of low oxygen saturation in a patient with glucose-6-phosphate dehydrogenase (G6PD) deficiency and variant hemoglobin (elevated HbA₂) on risperidone therapy, who exhibited no respiratory compromise.

CureusVol. 17(10)
University of Nigeria (NG), Fanshawe College (CA), University of Lagos (NG), Northern Arizona University (US), Johannesburg Hospital (ZA), Interfaith Medical Center (US), St. Christopher Iba Mar Diop College of Medicine (SN), Queens University (BD), Emory Johns Creek Hospital (US), Southwest Educational Development Center (US), Imo State University Teaching Hospital (NG), The Holly Private Hospital (GB), Olabisi Onabanjo University Teaching Hospital (NG), Olabisi Onabanjo University (NG), University of Toledo (US)
Openalex Percentile: Top 15%
Treatment of Major Depression
1.39
DOIOpen Access PDFOpenAlex
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Low Oxygen Saturation During Risperidone Therapy: A Multispecialty Approach — Olasumbo Elizabeth Fagbenle, Ogochukwu Agazie, et al. · Cureus (2025) | TGRS Research Map | TGRS