Evaluation of thermal desorption–electrospray ionization mass spectrometry for characterization of Mycobacterium tuberculosis: Comparison with MIRU-VNTR and whole-genome sequencing
Although TD-ESI/MS does not generate similar results from MTB molecular typing, it shows potential for identifying specific spectral signatures. The technique may be useful in future investigations into phenotypic diversity and other clinically relevant features not captured by genotyping alone.
Authors
- Shu-Huei Jain
- Hung Su (ORCID: https://orcid.org/0000-0003-1167-496X)
- Chao‐Ju Chen
- Jentaie Shiea (ORCID: https://orcid.org/0000-0002-7153-3029)
- Tsung-Ying Yang
- Hsien-Ho Lin (ORCID: https://orcid.org/0000-0002-7481-6016)
- Chieh-Yin Wu (ORCID: https://orcid.org/0000-0001-6024-6174)
- Po‐Liang Lu (ORCID: https://orcid.org/0000-0002-7423-6783)
Institutions
- National Sun Yat-sen University (TW)
- National Yang Ming Chiao Tung University (TW)
- Waseda University (JP)
- Kaohsiung Medical University (TW)
- National Taiwan University (TW)
- Kaohsiung Medical University Chung-Ho Memorial Hospital (TW)
- Mackay Medical University (TW)
Publication Details
- Journal
- Journal of Mass Spectrometry and Advances in the Clinical Lab
- Published
- 2025-10-26
- DOI
- https://doi.org/10.1016/j.jmsacl.2025.10.005
- Primary Topic
- Mycobacterium research and diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00