Defining the role of systemic autoimmune markers in adult epilepsy: A focus on autoimmune‐associated epilepsy

Autoimmune causes of epilepsy are increasingly recognized, and some patients may benefit from immunotherapy in addition to standard anti-seizure drugs. We retrospectively analyzed adult epilepsy patients by underlying cause and examined their clinical features, EEG findings, and blood tests for systemic autoantibodies. In our study, although these systemic autoantibodies were prevalent, they did not help predict seizure type, EEG pattern, or treatment outcome. However, we found that patients with seizure activity coming from several parts of the brain or frequent, hard-to-control seizures may have autoimmune-associated epilepsy and could benefit from advanced immune evaluation.