An undescribed ferulic acid ester from <i>Oreocome striata</i> (DC.) Pimenov &amp; Kljuykov and its anti-inflammatory activity

This study investigated the structural and anti-inflammatory properties of phenolic acids from <i>Oreocome striata</i> (DC.) Pimenov & Kljuykov. Phytochemical exploration yielded one undescribed ferulic acid ester - Oreocomeate A (<b>1</b>), along with eight known phenolic derivatives. Compound <b>1</b>'s 7'S,8'R configuration was assigned <i>via</i> combined spectroscopic analysis (HR-ESI-MS, NMR) and ECD calculations. Notably, compounds <b>2</b> and <b>4</b> were first reported as isolates from this plant family. In bioactivity evaluation, compound <b>1</b> exhibited the strongest NO inhibition with the IC₅₀ value of 15.71 ± 1.1 <i>μ</i>M. Molecular docking models suggested potential interactions between compounds <b>1-9</b> and MT-ND target, indicating a mechanistic basis for their modulation of inflammatory pathway. These findings collectively identify phenolic acids as key bioactive constituents underlying CX's traditional anti-inflammatory applications.