Epstein-Barr Virus Central Nervous System Infections and Mortality Risk in Patients Presenting With Suspected Meningitis: Results From the Botswana National Meningitis Survey and the Harare Meningitis Aetiology Study
EBV CNS infection was common among our cohort, and it was strongly associated with CSF pleocytosis. Following multivariable analyses, EBV CNS infection overall was not associated with in-hospital mortality rate. EBV CNS infection in the context of meningitis is most likely a "bystander" virus that reflects heightened CSF inflammation.
Authors
- Daniel J. Grint (ORCID: https://orcid.org/0000-0001-8001-6544)
- Gift Ngwende (ORCID: https://orcid.org/0000-0002-6131-2126)
- Taddy Mwarumba
- Takao MACHIYA
- William Hurt (ORCID: https://orcid.org/0000-0003-3803-9165)
- Samuel Ensor (ORCID: https://orcid.org/0000-0001-8456-9576)
- Hannah Barton (ORCID: https://orcid.org/0000-0002-6788-4213)
- Madisa Mine
- Ronan Doyle (ORCID: https://orcid.org/0000-0001-5001-1945)
- David A. Goldfarb (ORCID: https://orcid.org/0000-0003-0835-9504)
- Matthew Kinsella (ORCID: https://orcid.org/0000-0002-1715-3201)
- Mark W. Tenforde (ORCID: https://orcid.org/0000-0002-8702-8393)
- Lenon Gwaunza (ORCID: https://orcid.org/0000-0003-4367-8738)
- Leah A. Owen (ORCID: https://orcid.org/0000-0003-3802-3868)
- Imogen Mechie (ORCID: https://orcid.org/0000-0002-6310-6342)
- Thomas S. Harrison (ORCID: https://orcid.org/0000-0003-3619-4348)
- Keatlaretse Siamisang
- Jayne Ellis (ORCID: https://orcid.org/0000-0002-7009-9144)
- James Penney
- Tshepo Botho Leeme (ORCID: https://orcid.org/0000-0002-6153-4693)
- Tiny Mazhani (ORCID: https://orcid.org/0000-0001-9112-2174)
- Ezekiel Gwakuba
- James Milburn (ORCID: https://orcid.org/0000-0001-9885-6103)
- Kebatshabile Ngoni (ORCID: https://orcid.org/0000-0002-2763-712X)
- Rachita Suresh (ORCID: https://orcid.org/0009-0002-3317-179X)
- Joseph N Jarvis (ORCID: https://orcid.org/0000-0003-1459-5554)
- Cassie Northcott
- Chiratidzo E. Ndhlovu (ORCID: https://orcid.org/0000-0001-7863-7974)
- Síle F. Molloy (ORCID: https://orcid.org/0000-0001-8847-2325)
- Charles Muthoga (ORCID: https://orcid.org/0000-0002-3032-4829)
- Margaret Mokomane (ORCID: https://orcid.org/0000-0002-4406-3594)
- Janet Thubuka
- Christopher G. Williams (ORCID: https://orcid.org/0000-0003-3893-3124)
- George Manenji
Institutions
- University of London (GB)
- University of British Columbia (CA)
- University of Zimbabwe (ZW)
- University of Botswana (BW)
- St George's, University of London (GB)
- University of Washington (US)
- University of Exeter (GB)
- London School of Hygiene & Tropical Medicine (GB)
- Botswana Open University (BW)
- National Public Health Laboratory (NP)
- Princess Margaret Hospital (HK)
- Botswana Harvard AIDS Institute Partnership (BW)
- Institute of Infection and Immunity (CA)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2025-10-18
- DOI
- https://doi.org/10.1093/ofid/ofaf660
- Primary Topic
- Viral-associated cancers and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- OPEC Fund for International Development
- Wellcome Trust
- Government of the United Kingdom
- National Institute for Health and Care Research
- Department of Health and Social Care