The Eastern Cooperative Oncology Group Score Rather Than Donor Type Impacts Clinical Outcomes of Allogeneic Hematopoietic Stem Cell Transplantation in Severe Aplastic Anemia Patients Aged 51–60 Years: A Retrospective Study From the Chinese Blood and

Our study includes 103 patients aged between 51 and 60 years who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) from matched sibling donors (MSDs) (n = 36), haploidentical donors (HIDs) (n = 56), and unrelated donors (URDs) (n = 11). Multivariate analysis exploring the relationship between risk factors and survival confirmed that survival outcomes were only independently impacted by Eastern Cooperative Oncology Group (ECOG) score (ECOG scores ≥2 vs. ECOG scores of 0-1, overall survival [OS] HR: 2.91 [95% CI 1.35-6.27], p = 0.006; failure free survival [FFS] HR: 2.93 [95% CI 1.33-5.88], p = 0.006; graft-versus-host disease-free/relapse-free survival [GRFS] HR: 2.80 [95% CI 1.33-5.88], p = 0.006), while age, specific donor source and hematopoietic cell transplantation-comorbidity index (HCT-CI) score did not significantly influence prognosis in this age group. After applying propensity score-matching (PSM) to balance the pretransplant clinical factors between patients with ECOG scores 0-1 cohort and those with ECOG scores ≥2 cohort, poor performance status remains a negative factor for survival outcomes (OS p = 0.04; FFS p = 0.03; GRFS p = 0.03). Further analysis in subgroup patients with HCT-CI scores 0-1 found the retained significance of ECOG score in predicting inferior survival. In conclusion, our results indicate good long-term results of allo-HSCT in elderly SAA adults regardless of donor type. Higher ECOG score is associated with poor post-transplant outcomes and has to be taken into account for patients, even at a low-risk comorbidly burden.

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Publication Details

Journal
Clinical Transplantation
Published
2025-10-26
DOI
https://doi.org/10.1111/ctr.70359
Citations
1
Primary Topic
Hematopoietic Stem Cell Transplantation
Type
article
Field-Weighted Citation Impact
1.77
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article

The Eastern Cooperative Oncology Group Score Rather Than Donor Type Impacts Clinical Outcomes of Allogeneic Hematopoietic Stem Cell Transplantation in Severe Aplastic Anemia Patients Aged 51–60 Years: A Retrospective Study From the Chinese Blood and

Xiao‐Jun Huang, Kehong Bi, Hai Yi, Taiwu Xiao et al.
1 citations
Clinical Transplantation
Hematopoietic Stem Cell Transplantation
1.77
article

The Eastern Cooperative Oncology Group Score Rather Than Donor Type Impacts Clinical Outcomes of Allogeneic Hematopoietic Stem Cell Transplantation in Severe Aplastic Anemia Patients Aged 51–60 Years: A Retrospective Study From the Chinese Blood and

Xiao‐Jun Huang, Kehong Bi, Hai Yi, Taiwu Xiao, Zimin Sun, Dai‐Hong Liu, Erlie Jiang, Shun‐Qing Wang, Xianmin Song, Ge Bai, Fang Zhou, Guohong Su, Ming Zhou, Bao‐Dong Ye, Jinsong Yan, Guifang Ouyang, Huan Liu, Xin Li, Jianping Zhang, Lan‐Ping Xu, Xi Zhang, Ya‐Jing Xu, Jinxiong Huang, Weiwei Qin, Peihua Lu, Xin Zhao, Xuehong Ran, Xuejun Zhang
article en
1 citations

Abstract

Our study includes 103 patients aged between 51 and 60 years who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) from matched sibling donors (MSDs) (n = 36), haploidentical donors (HIDs) (n = 56), and unrelated donors (URDs) (n = 11). Multivariate analysis exploring the relationship between risk factors and survival confirmed that survival outcomes were only independently impacted by Eastern Cooperative Oncology Group (ECOG) score (ECOG scores ≥2 vs. ECOG scores of 0-1, overall survival [OS] HR: 2.91 [95% CI 1.35-6.27], p = 0.006; failure free survival [FFS] HR: 2.93 [95% CI 1.33-5.88], p = 0.006; graft-versus-host disease-free/relapse-free survival [GRFS] HR: 2.80 [95% CI 1.33-5.88], p = 0.006), while age, specific donor source and hematopoietic cell transplantation-comorbidity index (HCT-CI) score did not significantly influence prognosis in this age group. After applying propensity score-matching (PSM) to balance the pretransplant clinical factors between patients with ECOG scores 0-1 cohort and those with ECOG scores ≥2 cohort, poor performance status remains a negative factor for survival outcomes (OS p = 0.04; FFS p = 0.03; GRFS p = 0.03). Further analysis in subgroup patients with HCT-CI scores 0-1 found the retained significance of ECOG score in predicting inferior survival. In conclusion, our results indicate good long-term results of allo-HSCT in elderly SAA adults regardless of donor type. Higher ECOG score is associated with poor post-transplant outcomes and has to be taken into account for patients, even at a low-risk comorbidly burden.

Clinical TransplantationVol. 39(11)
Qingdao University (CN), Ningbo University (CN), Hebei Medical University (CN), Zhejiang Chinese Medical University (CN), University of Science and Technology of China (CN), Central South University (CN), Army Medical University (CN), Dalian Medical University (CN), Chinese Academy of Medical Sciences & Peking Union Medical College (CN), Peking University (CN), Chinese PLA General Hospital (CN), Liuzhou General Hospital (CN), Shanghai Stomatological Hospital (CN), 307th Hospital of Chinese People’s Liberation Army (CN), First Affiliated Hospital of Guangzhou Medical University (CN), Second Hospital of Hebei Medical University (CN), Second Affiliated Hospital of Dalian Medical University (CN), Cangzhou Central Hospital (CN), People's Liberation Army No. 150 Hospital (CN), Guangzhou Blood Center (CN), People's Liberation Army 401 Hospital (CN), Chengdu Military General Hospital (CN), Hebei Yiling Hospital (CN), Weifang People's Hospital (CN), Guangzhou First People's Hospital (CN), Xinqiao Hospital (CN), Peking University People's Hospital (CN), Shanghai First People's Hospital (CN), Shanghai Traditional Chinese Medicine Hospital (CN), Beijing Dao Pei Hospital (CN), Institute of Hematology & Blood Diseases Hospital (CN), Shandong Provincial QianFoShan Hospital (CN), Taian City Central Hospital (CN), Tang Du Hospital (CN), Third Xiangya Hospital (CN), Xiangya Hospital Central South University (CN), Liaocheng People's Hospital (CN), Shandong First Medical University (CN), Guangzhou Medical University (CN), Air Force Medical University (CN)
Openalex Percentile: Top 12%
Hematopoietic Stem Cell Transplantation
1.77
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