Improving detection and figures of merit in single-particle inductively coupled plasma-mass spectrometry via transient event heights
This is the first study to evaluate peak height as an analytical signal in SP-ICP-MS. The results highlight its advantages in specific applications, such as sizing NPs near the LoD, and in supporting the more reliable use of other signals, such as peak areas, by helping to identify incorrect threshold selection that could lead to biased distributions. Finally, monitoring peak heights allows for a more realistic and assumption-free determination of the LoD.
Authors
- Martín Resano (ORCID: https://orcid.org/0000-0002-7450-8769)
- Matilde Mataloni (ORCID: https://orcid.org/0009-0001-5556-3201)
- Ana Rua-Ibarz (ORCID: https://orcid.org/0000-0001-9582-6283)
- Maite Aramendía (ORCID: https://orcid.org/0000-0002-3916-9992)
- Eduardo Bolea‐Fernandez (ORCID: https://orcid.org/0000-0002-1856-2058)
- Marco Grotti (ORCID: https://orcid.org/0000-0001-6956-5761)
- Lorién López‐Villellas (ORCID: https://orcid.org/0000-0002-1891-4359)
- Antonio Bazo (ORCID: https://orcid.org/0000-0003-1603-2691)
Institutions
- Universidad de Zaragoza (ES)
- University of Genoa (IT)
Publication Details
- Journal
- Analytica Chimica Acta
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1016/j.aca.2025.344694
- Primary Topic
- Mass Spectrometry Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Università degli Studi di Genova
- Ministerio de Ciencia e Innovación
- Gobierno de Aragón
- European Regional Development Fund
- Agencia Estatal de Investigación
- Interreg