Fabrication of a new cobalt(II) complex by a nitrogenous substituted pyridinone ligand and its antitumor profile

A new chelate of a nitrogenous substituted pyridinone ligand, designated as [Co(AHPO)(H2O)2(OAc)2].3H2O, has been prepared. The structural properties of this novel compound were completely characterized via a variety of methods, such as FT-IR, CHN analyses, and UV-visible spectroscopy. FTIR revealed that The AHPO ligand works as a neutral OO bidentate ligand chelating the Co(II) ion thru both the oxygen atoms of the carbonyl groups. Furthermore, magnetic and molar conductance were measured. The conductometric analysis of the isolated [Co(AHPO)(H2O)2(OAc)2].3H2O chelate exhibited negligible molar conductance affirming the non-electrolytic behavior of Co(II) complex and the existence of acetate anion inside the coordination sphere. Also, thermal TG and DTG methods were employed. Whereas Coats-Redfern and Horowitz-Metzger models were applied to evaluate the thermodynamic and kinetic parameters of the Co(II) complex. Eventually, the in vitro antitumor screening of the investigated [Co(AHPO)(H2O)2(OAc)2].3H2O complex was examined against two different cell lines. This encompassed liver cancer (HePG-2) and breast cancer (MCF-7).