Functional divergence of MdpS and MdpS2 reveals mucin-targeting strategies in <i>Streptococcus oralis</i>
MdpS and MdpS2 exhibit complementary biochemical and functional profiles, supporting their roles in mucin degradation and biofilm remodelling. These findings advance our understanding of how early colonizing streptococci may interact with mucosal surfaces, influence biofilm dynamics and oral ecology, and suggest potential applications in targeting mucus-related disorders.
Authors
- Jonas Nilsson (ORCID: https://orcid.org/0000-0001-5263-2454)
- David J. Thornton (ORCID: https://orcid.org/0000-0001-7148-1970)
- Rolf Lood (ORCID: https://orcid.org/0000-0002-5974-0674)
- Gunnel Svensäter (ORCID: https://orcid.org/0000-0003-3173-7577)
- Liisa Arike (ORCID: https://orcid.org/0000-0002-2184-0960)
- Claes Wickström (ORCID: https://orcid.org/0000-0002-8183-8846)
- Sahana Kumar (ORCID: https://orcid.org/0000-0002-3295-3346)
- Fredrik Leo (ORCID: https://orcid.org/0000-0003-1605-5201)
- Gregg A. Duncan (ORCID: https://orcid.org/0000-0002-6811-1327)
- Emma Hilton (ORCID: https://orcid.org/0000-0002-3750-577X)
Institutions
- Malmö University (SE)
- Lund University (SE)
- Manchester Academic Health Science Centre (GB)
- Wellcome Centre for Cell-Matrix Research (GB)
- Genovis (Sweden) (SE)
- University of Maryland, College Park (US)
- University of Gothenburg (SE)
Publication Details
- Journal
- Journal of Oral Microbiology
- Published
- 2025-10-26
- DOI
- https://doi.org/10.1080/20002297.2025.2571186
- Primary Topic
- Glycosylation and Glycoproteins Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00