CD39 <sup>+</sup> CD4 <sup>+</sup> T cells influence cluster headache risk via ADP/N-acetylneuraminate and choline metabolic pathways: evidence from Mendelian Randomization
CD39<sup>+</sup> CD4<sup>+</sup> T cells may reduce CH risk by increasing the adenosine 5'-diphosphate (ADP) to N-acetylneuraminate ratio or the choline phosphate to phosphoethanolamine ratio. These findings provide novel insights into potential targets for the prevention and treatment of CH.
Authors
- Yun Zhu (ORCID: https://orcid.org/0000-0003-2268-5066)
- Jinsheng Zeng (ORCID: https://orcid.org/0000-0003-4280-0439)
- Ying Yi
- Hu Xie
Institutions
- Second Hospital of Yichang (CN)
Publication Details
- Journal
- International Journal of Neuroscience
- Published
- 2025-10-26
- DOI
- https://doi.org/10.1080/00207454.2025.2580332
- Primary Topic
- Migraine and Headache Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00