Lemierre Syndrome With Atypical Cardiological Involvement and Fatal Outcome

Lemierre syndrome, an uncommon but potentially fatal condition, begins in the throat, usually in the area surrounding the tonsils or pharynx, spreading to other parts of the body. Septic thrombophlebitis, marked by the blood clots in veins due to bacterial infection, is the hallmark of Lemierre syndrome. We describe a case of a 35-year-old male patient who presented with a sore throat, hoarseness, and swelling on the right side of the face and neck for one week, followed by a sudden onset of shortness of breath for one day. His condition deteriorated rapidly, and he was intubated and moved to the Intensive Care Unit. There was no recorded fever or history of fever. A moderate pericardial effusion was discovered by bedside echocardiogram. A computed tomography (CT) scan showed bilateral consolidation, septic emboli, mediastinal empyema, pulmonary embolism, and thrombosed veins. A positive blood culture for <i>Bacteroides</i> species confirmed the diagnosis of Lemierre syndrome. The patient's health worsened even with vigorous treatment, and, unfortunately, he passed away. Clinicians should maintain a high level of suspicion for this disease in patients with bacterial infection symptoms, especially originating in the head and neck regions, as well as in patients presenting with swelling of the neck. This report aims to provide valuable insights into the complexities of Lemierre syndrome, prompting further research and awareness to enhance early detection and improve outcomes for such critical individuals.

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Publication Details

Journal
Cureus
Published
2025-10-26
DOI
https://doi.org/10.7759/cureus.95424
Primary Topic
Otolaryngology and Infectious Diseases
Type
article
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article

Lemierre Syndrome With Atypical Cardiological Involvement and Fatal Outcome

Amara Zafar, Taymmia Ejaz, Shamsuddin Mir Jan, Aisha Jamal et al.
Cureus
Otolaryngology and Infectious Diseases
article

Lemierre Syndrome With Atypical Cardiological Involvement and Fatal Outcome

Amara Zafar, Taymmia Ejaz, Shamsuddin Mir Jan, Aisha Jamal, Marie-Christine Jaffar
article en

Abstract

Lemierre syndrome, an uncommon but potentially fatal condition, begins in the throat, usually in the area surrounding the tonsils or pharynx, spreading to other parts of the body. Septic thrombophlebitis, marked by the blood clots in veins due to bacterial infection, is the hallmark of Lemierre syndrome. We describe a case of a 35-year-old male patient who presented with a sore throat, hoarseness, and swelling on the right side of the face and neck for one week, followed by a sudden onset of shortness of breath for one day. His condition deteriorated rapidly, and he was intubated and moved to the Intensive Care Unit. There was no recorded fever or history of fever. A moderate pericardial effusion was discovered by bedside echocardiogram. A computed tomography (CT) scan showed bilateral consolidation, septic emboli, mediastinal empyema, pulmonary embolism, and thrombosed veins. A positive blood culture for <i>Bacteroides</i> species confirmed the diagnosis of Lemierre syndrome. The patient's health worsened even with vigorous treatment, and, unfortunately, he passed away. Clinicians should maintain a high level of suspicion for this disease in patients with bacterial infection symptoms, especially originating in the head and neck regions, as well as in patients presenting with swelling of the neck. This report aims to provide valuable insights into the complexities of Lemierre syndrome, prompting further research and awareness to enhance early detection and improve outcomes for such critical individuals.

CureusVol. 17(10)
Pakistan Army (PK), Aga Khan University Hospital (PK), Army Medical College (PK)
Openalex Percentile: Top 64%
Otolaryngology and Infectious Diseases
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Lemierre Syndrome With Atypical Cardiological Involvement and Fatal Outcome — Amara Zafar, Taymmia Ejaz, et al. · Cureus (2025) | TGRS Research Map | TGRS