A Longitudinal Multicenter Study Comparing the Effectiveness of Pharmacological and Lifestyle-Only Interventions in Adults With Prediabetes for Preventing Acute Hyperglycemic Crises and Progression to Type 2 Diabetes Mellitus
Both pharmacological and lifestyle interventions effectively improved metabolic outcomes among adults with prediabetes. However, pharmacological therapy provided modestly greater protection against disease progression and relapse. While the findings highlight the clinical value of early pharmacologic intervention, results should be interpreted with consideration of adherence variability and potential center-level differences. Larger randomized studies are warranted to confirm these observations.
Authors
- Talha Masood
- Naqeeb Ullah (ORCID: https://orcid.org/0009-0005-5021-1425)
- Sohail Abbas (ORCID: https://orcid.org/0000-0003-1194-064X)
- I. H. Khalil
- Muhammad Asad Ghufran (ORCID: https://orcid.org/0000-0002-6902-2297)
- Tauseef Ullah Shah
- Sarah Iqbal (ORCID: https://orcid.org/0000-0002-4857-4607)
- Manan Shah (ORCID: https://orcid.org/0000-0002-0362-4439)
- Sundas Safdar
- Hamza Usman
- Fatima Tu Zuhra
Institutions
- Khyber Teaching Hospital (PK)
- Lady Reading Hospital (PK)
- Hayatabad Medical Complex (PK)
- Northern Lincolnshire and Goole Hospitals NHS Foundation Trust (GB)
- General Sciences (United States) (US)
- Ziauddin Hospital (PK)
- Department of Public Health (US)
Publication Details
- Journal
- Cureus
- Published
- 2025-10-26
- DOI
- https://doi.org/10.7759/cureus.95420
- Primary Topic
- Diabetes Management and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00