Comment on ‘Exploring the neural basis of rosacea: altered brain activity and its links with social anxiety’

Song et al.’s study investigated the complex interaction between rosacea and the central nervous system using resting-state functional magnetic resonance imaging. Two key findings of the study indicate that right superior frontal gyrus activity correlates with erythema severity, forming a neurovascular bridge, and that left orbital middle frontal gyrus activity correlates with social anxiety, suggesting the neuropsychiatric signature of rosacea. These important findings highlight the need to consider neuropsychosocial pathways holistically in the treatment of rosacea and suggest structural neuroimaging and biomarker/treatment monitoring studies for future research.