Monoacylglycerol Lipase Inhibitor Mitigates Severe Acute Pancreatitis in Rats by Modulating the Gut Microbiota-Metabolite-Target Gene Interaction Network
JZL184 effectively mitigates SAP by reshaping the gut microbiota-metabolite-gene network, suppressing pathogenic bacteria and inflammatory pathways while restoring beneficial microbes and metabolic homeostasis. These findings support MAGL inhibition as a promising microbiota- targeted therapeutic strategy for SAP.
Authors
- Shulei Zhao (ORCID: https://orcid.org/0000-0002-9708-4807)
- Tong Su (ORCID: https://orcid.org/0000-0002-4272-3130)
- Lechang Zhang (ORCID: https://orcid.org/0009-0005-7827-6351)
- Tong Xiao (ORCID: https://orcid.org/0000-0003-1462-4650)
- Hongwei Xu (ORCID: https://orcid.org/0000-0002-0470-705X)
- Xiaohua Zhang (ORCID: https://orcid.org/0000-0002-0434-2863)
- Yuemin Feng (ORCID: https://orcid.org/0000-0003-3793-3237)
Institutions
- Shandong Provincial Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Endocrine Metabolic & Immune Disorders - Drug Targets
- Published
- 2025-10-26
- DOI
- https://doi.org/10.2174/0118715303405010251001114519
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00