Shepherin II Gene Synthesis and Peptide Characterization: E. coli Expression, Purification, and Antiviral Activity

This study demonstrated the feasibility of recombinant shepherin II production and assessed its antiviral activity. However, the limited selectivity index of shepherin II remains a challenge that needs to be addressed through molecular modification or alternative delivery strategies to improve its clinical potential.

Authors

Azza Atef (ORCID: https://orcid.org/0000-0001-6933-8091)
Safia Samir (ORCID: https://orcid.org/0000-0002-4121-0448)
Hend Okasha (ORCID: https://orcid.org/0000-0003-1125-245X)
S. M. Taha (ORCID: https://orcid.org/0000-0002-6825-466X)
Amal Ahmed Abd El-Fattah

Institutions

Ain Shams University (EG)
Theodor Bilharz Research Institute (EG)

Publication Details

Journal: Protein and Peptide Letters
Published: 2025-10-26
DOI: https://doi.org/10.2174/0109298665413796251002111415
Primary Topic: RNA and protein synthesis mechanisms
Type: article
Field-Weighted Citation Impact: 0.00

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article

Shepherin II Gene Synthesis and Peptide Characterization: E. coli Expression, Purification, and Antiviral Activity

Azza Atef, Safia Samir, Hend Okasha, S. M. Taha et al.

Oct 26, 2025

Protein and Peptide Letters

RNA and protein synthesis mechanisms

article

Shepherin II Gene Synthesis and Peptide Characterization: E. coli Expression, Purification, and Antiviral Activity

Azza Atef, Safia Samir, Hend Okasha, S. M. Taha, Amal Ahmed Abd El-Fattah

October 26, 2025article en

Abstract

This study demonstrated the feasibility of recombinant shepherin II production and assessed its antiviral activity. However, the limited selectivity index of shepherin II remains a challenge that needs to be addressed through molecular modification or alternative delivery strategies to improve its clinical potential.

Protein and Peptide LettersVol. 32(10)

Ain Shams University (EG), Theodor Bilharz Research Institute (EG)

Openalex Percentile: Top 73%

RNA and protein synthesis mechanisms

DOI Source OpenAlex

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Shepherin II Gene Synthesis and Peptide Characterization: E. coli Expression, Purification, and Antiviral Activity — Azza Atef, Safia Samir, et al. · Protein and Peptide Letters (2025) | TGRS Research Map | TGRS