A Case of Prolonged SARS-CoV-2 Shedding and HIV Co-infection: Clinical and Diagnostic Challenges

To our knowledge, this is the first study reporting accidental finding of HIV in a SARS-CoV-2 asymptomatic patient who was previously false negative. The persis-tence of SARS-CoV-2 in this case highlights the importance of comprehensive diagnostic workups and careful clinical management in patients with co-infections. This report also highlights the high risk of silent transmission of SARS-CoV-2 by asymptomatic individu-als, emphasizing the need to include such cases in dynamic surveillance strategies to pre-vent further spread. Along with this, the study highlights the need for further investigation into the interplay between HIV co-infection, COVID-19 vaccination outcomes, and the dynamics of SARS-CoV-2 shedding.