NFIC activates DEPTOR and blocks mTOR signaling to inhibit glycolysis and immune escape in oral squamous cell carcinoma
NFIC mediates DEPTOR transcription to repress mTOR signaling, thereby hindering OSCC progression by suppressing cell proliferation, glycolytic activity, and CD8<sup>+</sup> T cell-related immune escape.
Authors
- Jian Xu (ORCID: https://orcid.org/0000-0003-1816-4129)
- Lina Wang (ORCID: https://orcid.org/0009-0002-8518-8032)
- Xianwei Wang (ORCID: https://orcid.org/0000-0002-1490-8736)
- Yuxin Zou
- Min Sun (ORCID: https://orcid.org/0009-0007-6886-3565)
Institutions
- Harbin Medical University (CN)
- Heilongjiang Provincial Hospital (CN)
Publication Details
- Journal
- Archives of Oral Biology
- Published
- 2025-10-26
- DOI
- https://doi.org/10.1016/j.archoralbio.2025.106442
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00