Stable isotope tracing in human plasma-like medium reveals metabolic and immune modulation of the glioblastoma microenvironment
We present a tractable approach to assess glioma metabolism in vitro under physiologic nutrient levels and in the presence of an intact TME. This platform opens new avenues to interrogate glioma metabolism and its interplay with the immune microenvironment.
Authors
- Bradley Lega (ORCID: https://orcid.org/0000-0003-3634-406X)
- Samuel K. McBrayer (ORCID: https://orcid.org/0000-0001-9361-675X)
- Misty S. Martin-Sandoval (ORCID: https://orcid.org/0000-0002-7646-4181)
- Milan R. Savani (ORCID: https://orcid.org/0000-0003-1776-451X)
- Diana D. Shi (ORCID: https://orcid.org/0000-0002-6626-5277)
- Thomas P. Mathews (ORCID: https://orcid.org/0000-0002-9355-8243)
- Jacob Weiss
- Lauren C. Gattie (ORCID: https://orcid.org/0009-0002-9437-0610)
- Timothy E. Richardson (ORCID: https://orcid.org/0000-0001-7068-5517)
- William H. Hicks (ORCID: https://orcid.org/0000-0002-2689-3199)
- Lauren G. Zacharias (ORCID: https://orcid.org/0009-0007-7413-6460)
- Tracey Shipman (ORCID: https://orcid.org/0009-0004-4497-7080)
- Pascal Olivier Zinn (ORCID: https://orcid.org/0000-0003-0091-5887)
- Eric Y. Montgomery (ORCID: https://orcid.org/0000-0001-8255-2455)
- Kalil G. Abdullah (ORCID: https://orcid.org/0000-0002-5662-0829)
- Mohamad El Shami (ORCID: https://orcid.org/0000-0001-7345-4247)
- Yi Xiao (ORCID: https://orcid.org/0000-0002-3817-3471)
- Kenji Miki (ORCID: https://orcid.org/0000-0001-7424-0021)
- Bailey Smith (ORCID: https://orcid.org/0009-0001-4719-4581)
- Ralph J. DeBerardinis
- Skyler Oken
- Maged T Ghoche (ORCID: https://orcid.org/0009-0001-6679-681X)
- Lavanya N Katta
Institutions
- University of North Carolina at Chapel Hill (US)
- Howard Hughes Medical Institute (US)
- Harvard University (US)
- University of Pittsburgh (US)
- Southwestern Medical Center (US)
- University of Pittsburgh Medical Center (US)
- Dana-Farber Brigham Cancer Center (US)
- The University of Texas Southwestern Medical Center (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2025-10-22
- DOI
- https://doi.org/10.1093/neuonc/noaf248
- Citations
- 2
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 3.25
Funders
- Cancer Prevention and Research Institute of Texas
- Children’s Hospital of Wisconsin Research Institute
- National Institutes of Health
- National Cancer Institute