Analysis of Antibody Markers as Immune Correlates of Risk of Severe COVID-19 in the PREVENT-19 Efficacy Trial of the NVX-CoV2373 Recombinant Protein Vaccine
Post-vaccination NVX-CoV2373 antibody levels are stronger predictors of severe COVID-19 than any-severity Delta COVID-19. Low antibody responses indicate vulnerability to severe COVID-19.
Authors
- Rubén O. Donis (ORCID: https://orcid.org/0000-0001-6137-8312)
- Alice McGarry
- Michele P. Andrasik (ORCID: https://orcid.org/0000-0003-1952-7825)
- Yunda Huang (ORCID: https://orcid.org/0000-0003-1546-6172)
- Flora Castellino (ORCID: https://orcid.org/0000-0002-3432-9846)
- Richard A. Koup (ORCID: https://orcid.org/0000-0002-3090-7282)
- Christopher R. Houchens (ORCID: https://orcid.org/0000-0001-8125-4173)
- Christine B. Turley (ORCID: https://orcid.org/0000-0001-8079-9382)
- Ying Huang (ORCID: https://orcid.org/0000-0002-9655-7502)
- Iksung Cho (ORCID: https://orcid.org/0000-0001-5927-5410)
- Thomas Jones (ORCID: https://orcid.org/0000-0002-4097-1886)
- Maryam Keshtkar‐Jahromi (ORCID: https://orcid.org/0000-0001-8686-1036)
- James G. Kublin (ORCID: https://orcid.org/0000-0003-1279-3741)
- April K. Randhawa (ORCID: https://orcid.org/0000-0003-2652-3734)
- Lakshmi Jayashankar
- Christos J. Petropoulos (ORCID: https://orcid.org/0000-0001-5496-8090)
- Wayne Woo (ORCID: https://orcid.org/0000-0002-4272-4264)
- Cynthia L. Gay (ORCID: https://orcid.org/0000-0002-3620-3059)
- Kathleen M. Neuzil (ORCID: https://orcid.org/0000-0001-9480-2714)
- Yiwen Lu (ORCID: https://orcid.org/0000-0003-4921-7406)
- Julie A. Ake (ORCID: https://orcid.org/0000-0003-3831-5828)
- Karen Martins (ORCID: https://orcid.org/0000-0001-6536-3492)
- Dean A. Follmann (ORCID: https://orcid.org/0000-0003-4073-0393)
- Tatiana Beresnev (ORCID: https://orcid.org/0000-0001-9543-0107)
- Lawrence Corey (ORCID: https://orcid.org/0000-0002-2179-2436)
- Milagritos D. Tapia (ORCID: https://orcid.org/0000-0002-6476-3934)
- Chenchen Yu
- Deanne Haugaard
- Youyi Fong (ORCID: https://orcid.org/0000-0002-4230-6863)
- Elizabeth Barranco
- Germán Áñez (ORCID: https://orcid.org/0000-0001-5361-3001)
- Andrew Leith
- Lisa M. Dunkle (ORCID: https://orcid.org/0000-0003-2973-0245)
- Peter B. Gilbert (ORCID: https://orcid.org/0000-0002-2662-9427)
- Lindsay Nicole Carpp (ORCID: https://orcid.org/0000-0003-0333-5925)
- Julia Hütter (ORCID: https://orcid.org/0000-0002-7989-0450)
- Carina A. Rodriguez (ORCID: https://orcid.org/0000-0001-8687-9703)
- Susan E Kline (ORCID: https://orcid.org/0000-0001-8720-8688)
- Karen L. Kotloff
- Carmen Zorrilla (ORCID: https://orcid.org/0000-0001-7740-1636)
- William A. Webb
- Stuart H. Cohen
Institutions
- University of North Carolina at Charlotte (US)
- University of North Carolina at Chapel Hill (US)
- University of Maryland, Baltimore (US)
- National Institutes of Health (US)
- Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa (ZA)
- Minneapolis Institute of Arts (US)
- Infectious Disease Research Institute (US)
- University of Puerto Rico, Medical Sciences Campus (PR)
- Ponce Health Sciences University (PR)
- University of Washington (US)
- University of South Florida (US)
- Biomedical Advanced Research and Development Authority (US)
- LabCorp (United States) (US)
- University of Puerto Rico at Ponce (PR)
- Fred Hutch Cancer Center (US)
- Communities In Schools of Orange County (US)
- Novavax (United States) (US)
- Cancer Research And Biostatistics (US)
- Atrium Medical Cente (US)
- National Institute of Allergy and Infectious Diseases (US)
- University of Minnesota Medical Center (US)
- University of Washington Applied Physics Laboratory (US)
- University of California Davis Medical Center (US)
- California State University, Sacramento (US)
- Seattle University (US)
- University of Baltimore (US)
- Exelis (United States) (US)
- Walter Reed Army Institute of Research (US)
- University of Tampa (US)
Publication Details
- Journal
- Clinical Infectious Diseases
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1093/cid/ciaf558
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00