Comparison of percutaneous 60-day peripheral nerve stimulation of the lumbar medial branches to usual care with standard interventional management for chronic low back pain—a multicenter pragmatic randomized controlled trial (RESET)
This prospective multicenter pragmatic RCT met its Primary Clinical Endpoint and found that more participants with CLBP reported pain relief at 3 months after receiving percutaneous 60-day PNS as compared to usual care with standard interventional management. Participants treated with 60-day PNS showed greater reductions in pain and more substantial improvements in functional outcomes through 6 months.
Authors
- Morad Nasseri
- Mitchell Engle
- Thomas S. Lee (ORCID: https://orcid.org/0000-0001-7785-6761)
- Christopher A Gilmore (ORCID: https://orcid.org/0000-0002-8001-6867)
- Meredith J. McGee (ORCID: https://orcid.org/0000-0003-0823-3362)
- Kasra Amirdelfan (ORCID: https://orcid.org/0000-0002-1209-7247)
- Timothy R. Deer (ORCID: https://orcid.org/0000-0001-8907-7730)
- Steven Paul Cohen (ORCID: https://orcid.org/0000-0001-5928-2127)
- Mehul J. Desai (ORCID: https://orcid.org/0000-0001-6870-9436)
- Tristan Weaver
- Scott Davidoff
- Zachary L. McCormick (ORCID: https://orcid.org/0000-0002-2483-1090)
- William H. Clark (ORCID: https://orcid.org/0000-0002-7082-5986)
- Joseph W. Boggs (ORCID: https://orcid.org/0000-0002-7973-7990)
- Drew M Trainor
- Shivanand P. Lad (ORCID: https://orcid.org/0000-0003-4991-5319)
- Sean Li (ORCID: https://orcid.org/0000-0002-0492-1179)
- Michael J. DePalma (ORCID: https://orcid.org/0000-0003-1532-3438)
- Meenakshi Bindal
- Francesco Vetri
- Denise Lester (ORCID: https://orcid.org/0009-0003-3074-6057)
- Jessica Jameson
- Melissa A Tornero-Bold
Institutions
- Northwestern University (US)
- Virginia Department of Health (US)
- Main Line Health (US)
- John Muir Health (US)
- Duke University (US)
- Winston-Salem State University (US)
- University of Utah (US)
- University of Virginia Health System (US)
- Walter Reed National Military Medical Center (US)
- North Idaho College (US)
- Coeur d Alene Arthritis Clinic (US)
- Northwestern University (PH)
- Virginia Spine Research Institute (US)
- Sprint PNS System (United States) (US)
- Southeast Clinical Oncology Research Consortium (US)
- Pain Management Centers Of America (US)
- Millennium Pain Center (US)
- The Spine & Nerve Centers of the Virginias (US)
- Northwestern Medicine (US)
- VA Central California Health Care System (US)
- Duke University Hospital (US)
- Sensory Processing Disorder Foundation (US)
- International Spine, Pain & Performance (US)
- LifeBridge Health (US)
- The Ohio State University (US)
- Texas A&M University – Corpus Christi (US)
Publication Details
- Journal
- Pain Medicine
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1093/pm/pnaf147
- Citations
- 2
- Primary Topic
- Pain Management and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.38