The effect of Klotho protein on biological behavior of JEG-3 cells
Reduced Klotho protein expression in JEG-3 cells leads to increased IGF-1, decreased GH, enhanced cell proliferation and migration, elevated inflammatory responses, and metabolic imbalances, potentially contributing to placental dysfunction in growth-restricted fetuses.
Authors
- Jiajia Shen (ORCID: https://orcid.org/0000-0002-9186-321X)
- Guixiang Zeng
- Jie Lian (ORCID: https://orcid.org/0000-0003-3538-7746)
Institutions
- Guangxi Maternal and Child Health Hospital (CN)
- Children's Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Tissue and Cell
- Published
- 2025-10-25
- DOI
- https://doi.org/10.1016/j.tice.2025.103198
- Primary Topic
- Parathyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00