Interrelation between precisions on integrated currents and on recurrence times in Markov jump processes

For Markov jump processes on irreducible networks with a finite number of sites, we derive a general and explicit expression of the squared coefficient of variation for the net number of transitions from one site to a connected site in a given time window of observation (i.e., an 'integrated current' as dynamical output). Such an expression, which in itself is particularly useful for numerical calculations, is then elaborated to obtain the interrelation with the precision on the intrinsic timing of the recurrences of the forward and backward transitions. In biochemical ambits, such as enzyme catalysis and molecular motors, the precision on the timing is quantified by the so-called randomness parameter, and the above connection is established in the long time limit of monitoring and for an irreversible site-site transition; the present extension to finite time and reversibility adds a new dimension. Some kinetic and thermodynamic inequalities are also derived.

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Publication Details

Journal
Physical review. E
Published
2025-09-26
DOI
https://doi.org/10.1103/27gn-7w5d
Primary Topic
ATP Synthase and ATPases Research
Type
article
Field-Weighted Citation Impact
0.00

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article

Interrelation between precisions on integrated currents and on recurrence times in Markov jump processes

Alberto Garilli, Diego Frezzato
Physical review. E
ATP Synthase and ATPases Research
article

Interrelation between precisions on integrated currents and on recurrence times in Markov jump processes

Alberto Garilli, Diego Frezzato
article en

Abstract

For Markov jump processes on irreducible networks with a finite number of sites, we derive a general and explicit expression of the squared coefficient of variation for the net number of transitions from one site to a connected site in a given time window of observation (i.e., an 'integrated current' as dynamical output). Such an expression, which in itself is particularly useful for numerical calculations, is then elaborated to obtain the interrelation with the precision on the intrinsic timing of the recurrences of the forward and backward transitions. In biochemical ambits, such as enzyme catalysis and molecular motors, the precision on the timing is quantified by the so-called randomness parameter, and the above connection is established in the long time limit of monitoring and for an irreversible site-site transition; the present extension to finite time and reversibility adds a new dimension. Some kinetic and thermodynamic inequalities are also derived.

Physical review. EVol. 112(4)
University of Padua (IT)
Fondazione Cassa di Risparmio di Padova e Rovigo
Openalex Percentile: Top 73%
ATP Synthase and ATPases Research
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Interrelation between precisions on integrated currents and on recurrence times in Markov jump processes — Alberto Garilli, Diego Frezzato · Physical review. E (2025) | TGRS Research Map | TGRS