Investigation into the Utility of Visible‐Light‐Initiated Decarboxylative Radical Addition of Amino Acids to Alkenes, With Applications in the Synthesis of Alkaloid Scaffolds

Abstract The present study investigates the versatility of visible‐light‐initiated decarboxylation of amino acids, resulting in the formation of an α‐amino radical. Herein, we have delineated the comprehensive scope and limitations of Giese's addition to electron‐deficient alkenes. Furthermore, we have demonstrated the extendibility of this concept to electron‐rich styrene derivatives. This strategy has been demonstrated to suppress other reactions recently reported for this type of reagents, thereby providing target products with high yields. The designed methodology facilitates the functionalisation of bioactive molecules during the advanced stages of the process. We have illustrated that the developed transformation has significant potential for further applications in the synthesis of bicyclic alkaloid skeletons.