Nicotinamide mononucleotide rescues Di-n-butyl phthalate induced blood-brain barrier damage via NAD+/Sirt1/FOXO1a pathway activation
DBP disrupts BBB integrity and cognitive function through NAD<sup>+</sup> depletion-driven suppression of the Sirt1/FOXO1a pathway. NMN counteracts these effects, suggesting its potential as a therapeutic agent against environmental neurotoxins.
Authors
- Haoyuan Yin (ORCID: https://orcid.org/0000-0002-1437-6063)
- Yanqing Song (ORCID: https://orcid.org/0000-0001-6725-3342)
- Yuhao Zhao (ORCID: https://orcid.org/0000-0002-9014-5259)
- Jianhua Ma (ORCID: https://orcid.org/0000-0001-9383-2559)
- Xuan Chen (ORCID: https://orcid.org/0000-0001-5553-3638)
- Huan Gao (ORCID: https://orcid.org/0000-0001-5072-841X)
- Renjie Liu (ORCID: https://orcid.org/0000-0001-9897-7386)
- Zhongxi Yang (ORCID: https://orcid.org/0009-0005-0941-0692)
- Jiahui Feng (ORCID: https://orcid.org/0009-0004-7143-6159)
Institutions
- Jilin University (CN)
- First Hospital of Jilin University (CN)
Publication Details
- Journal
- Ecotoxicology and Environmental Safety
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1016/j.ecoenv.2025.119290
- Primary Topic
- Anesthesia and Neurotoxicity Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00