Establishing Triple Chronotherapy as a fast-acting add-on treatment for unipolar and bipolar depression: evidence from an open-label randomized controlled trial in a real-world inpatient setting
These findings suggest that add-on TCT can rapidly reduce depressive symptoms and improve associated outcomes in hospitalized patients with moderate MDEs. Future research with larger samples and longer follow-ups should further explore TCT's efficacy and safety, aiming to optimize treatment strategies for depressive episodes.
Authors
- Stefano Terzoni (ORCID: https://orcid.org/0000-0002-0716-5663)
- Simone Cavallotti
- Claudia Carrara
- C. Ossola
- Hans‐Christian Stein (ORCID: https://orcid.org/0000-0002-3662-1752)
- Armando D’Agostino (ORCID: https://orcid.org/0000-0002-2126-799X)
- Barbara Giordano (ORCID: https://orcid.org/0000-0001-9262-079X)
- Edoardo Giuseppe Ostinelli (ORCID: https://orcid.org/0000-0002-8717-0832)
- Paolo Ferrara (ORCID: https://orcid.org/0000-0001-5366-4132)
- Giovanni Broglia
- Stefano Masier
- Rosa Panarello
Institutions
- AOL (United States) (US)
- University of Milan (IT)
- South London and Maudsley NHS Foundation Trust (GB)
- National Institute for Health and Care Research (GB)
- Ospedale San Paolo (IT)
- Azienda Socio Sanitaria Territoriale Santi Paolo e Carlo
Publication Details
- Journal
- Journal of Affective Disorders
- Published
- 2025-10-25
- DOI
- https://doi.org/10.1016/j.jad.2025.120537
- Primary Topic
- Mental Health Research Topics
- Type
- article
- Field-Weighted Citation Impact
- 0.00