A Facile, One‐Pot, and Sustainable Synthesis of Poly‐Substitute Quinoline Analogs by Ag ₂ O@GO as a Promising Catalyst

Abstract A novel and environmentally sustainable approach has been developed for the efficient one‐pot synthesis of poly‐substitute quinoline analogs using a silver oxide‐graphene oxide (Ag 2 O@GO) nanocomposite catalyst. This multi‐component reaction leverages the synergistic properties of the nanocomposite, which was thoroughly characterized through BET surface area analysis, PXRD, SEM, TEM, EDX, and TGA. The catalyst stands out for its simplicity of preparation, cost‐effectiveness, nontoxicity, and exceptional stability making it an attractive option for sustainable synthesis. Structural confirmation of all target compounds was achieved using 1 H‐NMR, 13 C‐NMR, 15 N‐NMR, and HRMS analyses. The protocol offers significant practical advantages, including mild reaction conditions, high yields (93%–97%), reduced reaction times, and the elimination of chromatographic purification. Furthermore, the catalyst demonstrates excellent reusability, maintaining consistent performance over at least seven consecutive cycles without notable loss in activity. By combining efficiency with environmental consciousness, this approach represents a meaningful advancement in green synthetic methodologies, providing a viable alternative to conventional techniques.