HLA class I expression shapes the tumor immune microenvironment and influences prognosis in prostate cancer
In PC, elevated HLA class I levels correlate with immune activity, molecular characteristics, and clinical outcomes. We suggest considering HLA expression as a supplementary marker of immune activity in PC, alongside genetic mutations and transcriptomic markers.
Authors
- Negar Sadeghipour
- Nicholas A. Zorko (ORCID: https://orcid.org/0000-0001-7021-968X)
- Andrew Elliott (ORCID: https://orcid.org/0000-0001-8494-8031)
- James Hamrick (ORCID: https://orcid.org/0000-0002-0319-140X)
- Laura A. Sena (ORCID: https://orcid.org/0000-0001-6724-9546)
- Ali T. Arafa
- Alexander K. Tsai (ORCID: https://orcid.org/0000-0002-4014-1946)
- Martin Felices (ORCID: https://orcid.org/0000-0002-5945-0634)
- Lisa N. Chesner (ORCID: https://orcid.org/0009-0007-2779-8824)
- Vivek Narayan (ORCID: https://orcid.org/0000-0002-8205-738X)
- Akash Patnaik (ORCID: https://orcid.org/0000-0001-5306-0208)
- Philippa R Kennedy (ORCID: https://orcid.org/0000-0003-0239-5440)
- Rachel Passow (ORCID: https://orcid.org/0009-0003-9822-6525)
- Justin H. Hwang (ORCID: https://orcid.org/0000-0003-1686-7103)
- Emmanuel S. Antonarakis (ORCID: https://orcid.org/0000-0003-0031-9655)
- Carissa Besonen (ORCID: https://orcid.org/0009-0008-6586-800X)
Institutions
- Creighton University (US)
- University of Minnesota (US)
- Siriraj Hospital (TH)
- University of California, San Francisco (US)
- Mahidol University (TH)
- University of Chicago (US)
- Twin Cities Orthopedics (US)
- Caris Life Sciences (United States) (US)
- Sidney Kimmel Comprehensive Cancer Center (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Prostate Cancer and Prostatic Diseases
- Published
- 2025-10-25
- DOI
- https://doi.org/10.1038/s41391-025-01045-9
- Citations
- 1
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- U.S. Department of Defense
- University of Minnesota
- National Cancer Institute