Quality of life following total neoadjuvant therapy for rectal cancer
LARC patients undergoing TNT showed comparable HRQoL outcomes to CRC patients treated with curative intent, but with reductions when compared to the general population. The presence of chronic toxicity significantly impacts HRQoL. Survivors may experience HRQoL impairments post-TNT, underscoring the necessity for ongoing management of chronic toxicity tailored to their needs.
Authors
- Andreas Hinz (ORCID: https://orcid.org/0000-0002-6986-8145)
- Jan-Niklas Becker (ORCID: https://orcid.org/0000-0001-6972-0899)
- Melanie Schneider
- Maximilian Römer (ORCID: https://orcid.org/0000-0002-7069-4699)
- Adrianna Cieślak (ORCID: https://orcid.org/0000-0001-7793-5494)
- Alexander Rühle (ORCID: https://orcid.org/0000-0003-2022-897X)
- Markus Diefenhardt (ORCID: https://orcid.org/0000-0002-9042-9729)
- Klaus Pietschmann (ORCID: https://orcid.org/0009-0002-8085-8455)
- Georg Wurschi (ORCID: https://orcid.org/0000-0002-8751-9862)
- Felix Ehret (ORCID: https://orcid.org/0000-0001-6177-1755)
- Florian Rißner
- Justus Kaufmann (ORCID: https://orcid.org/0000-0003-0189-3499)
- Maren Schöneich
- Alina Depardon
- Hai Minh Ha
- Daphne Schepers von Ohlen
Institutions
- Goethe University Frankfurt (DE)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Johannes Gutenberg University Mainz (DE)
- Heidelberg University (DE)
- University Medical Center Freiburg (DE)
- University Hospital Heidelberg (DE)
- Medizinische Hochschule Hannover (DE)
- Humboldt-Universität zu Berlin (DE)
- Universitätsklinikum Erlangen (DE)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- German Cancer Society (DE)
- University Hospital Schleswig-Holstein (DE)
- Jena Bioscience (Germany) (DE)
- University Hospital Leipzig (DE)
- German Centre for Cardiovascular Research (DE)
- University Hospital Frankfurt (DE)
- Jena University Hospital (DE)
- University Medical Centre Mannheim (DE)
- Frankfurt Cancer Institute (DE)
- University Hospital Carl Gustav Carus (DE)
- Technische Universität Dresden (DE)
- Leipzig University (DE)
- University of Lübeck (DE)
- Otto-von-Guericke-Universität Magdeburg (DE)
Publication Details
- Journal
- Journal of Cancer Research and Clinical Oncology
- Published
- 2025-10-25
- DOI
- https://doi.org/10.1007/s00432-025-06347-y
- Citations
- 2
- Primary Topic
- Colorectal Cancer Surgical Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- Universitätsklinikum Jena