Prodromal symptoms in amyotrophic lateral sclerosis from the perspective of the patient and of the caregiver
In sporadic ALS, approximately a quarter of patients report a prodromal phase characterized primarily by mild motor symptoms. However, mild motor symptoms alone are unlikely to contribute to earlier disease recognition. Cognitive or behavioral symptoms are often not recognized as part of the clinical spectrum. These findings emphasize the need for reliable biomarkers to detect ALS pathology at an early stage.
Authors
- Henk‐Jan Westeneng (ORCID: https://orcid.org/0000-0001-7138-3852)
- Lisa Kraneburg (ORCID: https://orcid.org/0000-0002-8805-5617)
- Ruben P. A. van Eijk (ORCID: https://orcid.org/0000-0002-7132-5967)
- Leonard H. van den Berg (ORCID: https://orcid.org/0000-0002-5203-9674)
- Jan H. Veldink (ORCID: https://orcid.org/0000-0001-5572-9657)
- Michael A. van Es (ORCID: https://orcid.org/0000-0002-7709-5883)
- Iris F. van Wijk (ORCID: https://orcid.org/0000-0003-4775-0282)
Institutions
- University Medical Center Utrecht (NL)
Publication Details
- Journal
- Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
- Published
- 2025-10-25
- DOI
- https://doi.org/10.1080/21678421.2025.2574687
- Citations
- 1
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 1.39