Enhanced effects of photodynamic therapy and celecoxib on the triple‑negative breast cancer MDA‑MB‑231 cell line: Impact on BCL‑2, BAX, and TP53 gene expression
Our findings suggest that combining celecoxib with methylene blue-mediated PDT may enhance apoptosis and cytotoxicity in MDA-MB-231 BC cells by modulating key apoptotic and DNA damage response genes. This combined approach holds promise as a potential therapeutic strategy; however, further validation in vivo and in clinical settings is warranted.
Authors
- Fatemeh Asgari (ORCID: https://orcid.org/0009-0003-4903-3217)
- Soyar Sari (ORCID: https://orcid.org/0000-0002-2503-1327)
- Fatemeh Javani Jouni
- Jaber Zafari (ORCID: https://orcid.org/0000-0002-4483-6016)
- Parisa Ashrafi
Institutions
- Islamic Azad University, Tehran (IR)
- Islamic Azad University Medical Branch of Tehran (IR)
Publication Details
- Journal
- Photodiagnosis and Photodynamic Therapy
- Published
- 2025-10-22
- DOI
- https://doi.org/10.1016/j.pdpdt.2025.105263
- Citations
- 1
- Primary Topic
- Click Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.94