TAAR1 Regulates Presynaptic Dopamine Function: Evidence From Preclinical Studies and a Phase 1b Trial in Patients With Schizophrenia

TAAR1 regulates DA synthesis and release. Adjunctive ulotaront reduces presynaptic DA function and psychotic symptoms in schizophrenia. These findings support TAAR1 as a promising target for treating antipsychotic nonresponsive schizophrenia and other dopaminergic disorders.

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Publication Details

Journal
Biological Psychiatry
Published
2025-10-01
DOI
https://doi.org/10.1016/j.biopsych.2025.10.013
Citations
1
Primary Topic
Receptor Mechanisms and Signaling
Type
article
Field-Weighted Citation Impact
0.81

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article

TAAR1 Regulates Presynaptic Dopamine Function: Evidence From Preclinical Studies and a Phase 1b Trial in Patients With Schizophrenia

Oliver Howes, Eugenii A. Rabiner, Snezana Milanovic, Nina Dedic et al.
1 citations
Biological Psychiatry
Receptor Mechanisms and Signaling
0.81
article

TAAR1 Regulates Presynaptic Dopamine Function: Evidence From Preclinical Studies and a Phase 1b Trial in Patients With Schizophrenia

Oliver Howes, Eugenii A. Rabiner, Snezana Milanovic, Nina Dedic, Dominic J. Withers, Lisa Wells, Stephen J. Kaar, Mattia Veronese, Giovanna Nordio, Sridhar Natesan, Seth C. Hopkins, Emanuel F. Lopes, Luke James Vano, Grazia Rutigliano, Robert Ali McCutcheon, Kenneth S. Koblan, Stephanie J. Cragg, Alice Petty
article en
1 citations

Abstract

TAAR1 regulates DA synthesis and release. Adjunctive ulotaront reduces presynaptic DA function and psychotic symptoms in schizophrenia. These findings support TAAR1 as a promising target for treating antipsychotic nonresponsive schizophrenia and other dopaminergic disorders.

Biological Psychiatry
King's College London (GB), South London and Maudsley NHS Foundation Trust (GB), Hammersmith Hospital (GB), University of Oxford (GB), Neuroscience Institute (IT), Sumitomo Dainippon Pharma (United States) (US), MRC London Institute of Medical Sciences (GB)
Wellcome Trust, National Institute for Health and Care Research, Department of Health and Social Care, European Commission, Medical Research Council
Openalex Percentile: Top 22%
Receptor Mechanisms and Signaling
0.81
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