TAAR1 Regulates Presynaptic Dopamine Function: Evidence From Preclinical Studies and a Phase 1b Trial in Patients With Schizophrenia
TAAR1 regulates DA synthesis and release. Adjunctive ulotaront reduces presynaptic DA function and psychotic symptoms in schizophrenia. These findings support TAAR1 as a promising target for treating antipsychotic nonresponsive schizophrenia and other dopaminergic disorders.
Authors
- Oliver Howes (ORCID: https://orcid.org/0000-0002-2928-1972)
- Eugenii A. Rabiner (ORCID: https://orcid.org/0000-0003-3612-6687)
- Snezana Milanovic (ORCID: https://orcid.org/0009-0000-7586-1583)
- Nina Dedic (ORCID: https://orcid.org/0009-0000-3769-725X)
- Dominic J. Withers (ORCID: https://orcid.org/0000-0002-8009-7521)
- Lisa Wells
- Stephen J. Kaar (ORCID: https://orcid.org/0000-0003-0194-0806)
- Mattia Veronese (ORCID: https://orcid.org/0000-0003-3562-0683)
- Giovanna Nordio (ORCID: https://orcid.org/0000-0002-7835-2992)
- Sridhar Natesan (ORCID: https://orcid.org/0000-0001-7499-1714)
- Seth C. Hopkins (ORCID: https://orcid.org/0000-0003-3999-2281)
- Emanuel F. Lopes (ORCID: https://orcid.org/0000-0003-1426-8350)
- Luke James Vano (ORCID: https://orcid.org/0000-0003-1624-490X)
- Grazia Rutigliano (ORCID: https://orcid.org/0000-0001-6014-5357)
- Robert Ali McCutcheon (ORCID: https://orcid.org/0000-0003-1102-2566)
- Kenneth S. Koblan (ORCID: https://orcid.org/0000-0001-6103-2629)
- Stephanie J. Cragg (ORCID: https://orcid.org/0000-0001-9677-2256)
- Alice Petty (ORCID: https://orcid.org/0000-0001-7058-4185)
Institutions
- King's College London (GB)
- South London and Maudsley NHS Foundation Trust (GB)
- Hammersmith Hospital (GB)
- University of Oxford (GB)
- Neuroscience Institute (IT)
- Sumitomo Dainippon Pharma (United States) (US)
- MRC London Institute of Medical Sciences (GB)
Publication Details
- Journal
- Biological Psychiatry
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1016/j.biopsych.2025.10.013
- Citations
- 1
- Primary Topic
- Receptor Mechanisms and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Wellcome Trust
- National Institute for Health and Care Research
- Department of Health and Social Care
- European Commission
- Medical Research Council