Differential impact of manganese on glutamate clearance, electroencephalography, and sleep in Alzheimer's disease
Manganese exposure significantly alters glutamate clearance dynamics differentially in wild-type and APP/PSEN1 mouse models of Alzheimer's disease. Acute manganese treatment disrupts sleep architecture, evidenced by changes in electroencephalography (EEG) patterns and vigilance states. APP/PSEN1 mice exhibit slower glutamate clearance and altered gene expression compared to wild-type mice following manganese exposure. Distinct brain wave frequency shifts were observed in response to manganese treatment, particularly affecting delta, theta, and alpha rhythms. Findings suggest a potential exacerbation of excitatory/inhibitory imbalances due to environmental manganese exposure in Alzheimer's pathology.
Authors
- Aaron B. Bowman
- Erin S. Calipari (ORCID: https://orcid.org/0000-0003-4723-0623)
- Alec T. Kramer
- William P. Nobis (ORCID: https://orcid.org/0000-0002-2318-6077)
- Rebecca A. Buchanan (ORCID: https://orcid.org/0000-0003-2510-4140)
- Fiona E. Harrison (ORCID: https://orcid.org/0000-0003-1121-0647)
Institutions
- Vanderbilt University (US)
- Purdue University West Lafayette (US)
- Vanderbilt Health (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/alz.70821
- Primary Topic
- Anesthesia and Neurotoxicity Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Vanderbilt University
- Vanderbilt Kennedy Center, Vanderbilt University Medical Center
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Institute of Child Health and Human Development
- Eunice Kennedy Shriver National Institute of Child Health and Human Development