Alzheimer's disease and its progression reduce pyramidal cell gain and connectivity
Magnetoencephalography scanning provides reliable biomarkers that are sensitive to Alzheimer's disease (AD) and its progression, and informative about disease mechanisms underlying cognitive decline. In vivo assays of pyramidal cell function during cognitive processes in humans improve our understanding of AD mechanisms. The amplitude of the mismatch negativity response is progressively reduced in AD. Reduced pyramidal cell gain and connectivity underlie this neurophysiological deficit. These measures are potential biomarkers for interventional studies.
Authors
- Melek Karadag
- Michael S. Perkinton (ORCID: https://orcid.org/0000-0003-1130-7844)
- Juliette H. Lanskey (ORCID: https://orcid.org/0000-0002-6626-7686)
- James B. Rowe (ORCID: https://orcid.org/0000-0001-7216-8679)
- Vanessa Raymont (ORCID: https://orcid.org/0000-0001-8238-4279)
- Richard N. Henson (ORCID: https://orcid.org/0000-0002-0712-2639)
- Amirhossein Jafarian (ORCID: https://orcid.org/0000-0001-9547-7941)
- Tony Thayanandan (ORCID: https://orcid.org/0000-0001-9470-5404)
- Andrew J. Quinn (ORCID: https://orcid.org/0000-0003-2267-9897)
- Anna Christina Nobre (ORCID: https://orcid.org/0000-0001-5762-2802)
- Pranay Yadav (ORCID: https://orcid.org/0000-0002-9368-8398)
- R Williams (ORCID: https://orcid.org/0000-0001-7645-7398)
- Ece Kocagöncü (ORCID: https://orcid.org/0000-0002-6292-7472)
- Maarten Timmers (ORCID: https://orcid.org/0000-0002-0257-9314)
- Krish D. Singh (ORCID: https://orcid.org/0000-0002-3094-2475)
- Jemma Pitt (ORCID: https://orcid.org/0000-0001-6256-6091)
- Mark W. Woolrich (ORCID: https://orcid.org/0000-0001-8460-8854)
- Stephen L. Lowe
Institutions
- Johnson & Johnson (United States) (US)
- Janssen (Belgium) (BE)
- Eli Lilly (United States) (US)
- MRC Cognition and Brain Sciences Unit (GB)
- University of Cambridge (GB)
- Cambridge University Hospitals NHS Foundation Trust (GB)
- University of Oxford (GB)
- Wellcome Centre for Integrative Neuroimaging (GB)
- AstraZeneca (Spain) (ES)
- Cardiff University (GB)
- University of Birmingham (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/alz.70805
- Primary Topic
- Neural dynamics and brain function
- Type
- article
- Field-Weighted Citation Impact
- 0.00